Endocrine Abstracts

Introduction:The ovarian surface epithelium (OSE) covers the surface of the ovary, and is subjected to rupture and repair during ovulation. Ovulation bears hallmarks of a wound / heal event, including inflammation. Though integral to ovulation, inflammation may cause cellular damage leading to ovarian tumours, of which >90% are OSE derived. Progesterone, produced in large amounts at ovulation, has anti-inflammatory properties. The aim of this study wa...

IntroductionThe process of ovulation is believed to contribute to the majority of ovarian cancers that derive from the ovarian surface epithelium (OSE). The OSE is known to be important for successful ovulation and more recently was shown to be sensitive to inflammatory cytokines such as interleukin-1alpha (IL-1alpha; Human Reproduction: 17:2300-2306).MethodsNormal OSE cells were obtained, with informed conse...

IntroductionBased upon epidemiological evidence linking hyperthyroidism, inflammation of the ovarian surface and increased risk of ovarian cancer development, we have studied thyroid receptor expression in human ovarian surface epithelial cells (hOSE), and examined the possibility that triiodothyronine (T3) may have direct effects on hOSE cells, the origin of the vast majority of ovarian tumours.MethodsHuman ...

IntroductionOvulation involves rupture of the ovarian surface, and thus the ovarian surface epithelium (OSE) is subjected to serial injury and repair with each ovulatory cycle. Inflammation is integral to the process of ovulation, but importantly, inflammatory damage is also thought to be a potential mechanism of ovarian tumour development. We have examined OSE responses to an inflammatory stimulus associated with ovulation, Interleukin-1alpha (IL1alpha)...